Ontology highlight
ABSTRACT:
SUBMITTER: Hou DR
PROVIDER: S-EPMC6269665 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Hou Duen-Ren DR Huang Ann-Chi AC Shiau Chung-Wai CW Wang Chun-Yi CY Yu Hui-Chuan HC Chen Kuen-Feng KF
Molecules (Basel, Switzerland) 20131211 12
CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis. Here; we modified the functional group of bortezomib to generate a series of novel compounds and conducted a structure-activity relationship (SAR) study. The results showed that compound 1 was able to repress CIP2A expression and cell apoptosis in the same manner as bortezomib, but with less potency in i ...[more]