Ontology highlight
ABSTRACT:
SUBMITTER: Gayen S
PROVIDER: S-EPMC6269726 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Gayen Shovanlal S Li Qingxin Q Kim Young Mee YM Kang CongBao C
Molecules (Basel, Switzerland) 20130722 7
The C-terminal domains of the Frizzleds (FZDs) contain a short conserved motif (KTXXXW). It has been demonstrated that FZDs interacted with the PDZ domain of the cytoplasmic proteins such as Dishevelled through this motif and mutations in this motif disrupted Wnt/β-catenin signaling. We carried out structural studies for a peptide derived from the C-terminal domain of the FZD1 in different solvents using circular dichroism and solution NMR spectroscopy. Our results showed that this domain was un ...[more]