Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC6270099 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Liu Zheng Z Li Wei W Wen Hong-Mei HM Bian Hui-Min HM Zhang Jing J Chen Lei L Chen Long L Yang Kun-Di KD
Molecules (Basel, Switzerland) 20130418 4
Liguzinediol (LZDO) ester prodrugs 3-5 were synthesized and evaluated in vitro and in vivo for their potential use in prolonging the half-life of the parent drug LZDO (1a) in vivo. Prodrugs 3-5 were found to display a potent positive inotropic effect on the myocardium, without the risk of arrhythmia. Prodrugs 3-5 rapidly underwent enzymatic hydrolysis to release the parent compound LZDO in 1-3 h in rat liver microsomes and rat plasma. The half-life of the parent compound was prolonged after intr ...[more]