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Synthesis and thermotropic phase behavior of four glycoglycerolipids.

ABSTRACT: Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.

SUBMITTER: Hogendorf WF

PROVIDER: S-EPMC6270285 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Synthesis and thermotropic phase behavior of four glycoglycerolipids.

Hogendorf Wouter F J WF Jagalski Vivien V Pomorski Thomas G TG Bols Mikael M Cárdenas Marité M Pedersen Christian M CM

Molecules (Basel, Switzerland) 20131101 11

Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depend ...[more]

PMID: 24189295

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