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Loddigesiinols G-J: ?-glucosidase inhibitors from Dendrobium loddigesii.

ABSTRACT: Four new polyphenols, loddigesiinols G-J (compounds 1-4) and a known compound, crepidatuol B (5), were isolated from the stems of Dendrobium loddigesii that have long been used in Traditional Chinese Medicine and have recently been used to treat type 2 diabetes. Compounds 1-5 structures were elucidated based on spectroscopic analysis. The absolute configurations of compounds 1-4 were determined using theoretical calculations of electronic circular dichroism (ECD), and the absolute configuration of compound 5 was determined by a comparison of the experimental ECD spectra and the literature data. Compounds 1-5 are strong inhibitors of ?-glucosidase, with IC50 values of 16.7, 10.9, 2.7, 3.2, and 18.9 ?M, respectively. Their activities were significantly stronger than trans-resveratrol as a positive control (IC50 values of 27.9 ?M).

SUBMITTER: Lu Y

PROVIDER: S-EPMC6270667 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Loddigesiinols G-J: α-glucosidase inhibitors from Dendrobium loddigesii.

Lu Yu Y Kuang Ming M Hu Gu-Ping GP Wu Rui-Bo RB Wang Jun J Liu Lan L Lin Yong-Cheng YC

Molecules (Basel, Switzerland) 20140623 6

Four new polyphenols, loddigesiinols G-J (compounds 1-4) and a known compound, crepidatuol B (5), were isolated from the stems of Dendrobium loddigesii that have long been used in Traditional Chinese Medicine and have recently been used to treat type 2 diabetes. Compounds 1-5 structures were elucidated based on spectroscopic analysis. The absolute configurations of compounds 1-4 were determined using theoretical calculations of electronic circular dichroism (ECD), and the absolute configuration ...[more]

PMID: 24959681

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