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Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.

ABSTRACT: Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm×4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.

SUBMITTER: Cheng ZG

PROVIDER: S-EPMC6270734 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.

Cheng Zhi-Gang ZG Dai Xu-Yong XY Li Li-Wei LW Wan Qiong Q Ma Xiang X Xiang Guang-Ya GY

Molecules (Basel, Switzerland) 20140121 1

Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm×4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The i ...[more]

PMID: 24451253

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