Ontology highlight
ABSTRACT:
SUBMITTER: Klotz LO
PROVIDER: S-EPMC6270801 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Klotz Lars-Oliver LO Hou Xiaoqing X Jacob Claus C
Molecules (Basel, Switzerland) 20140917 9
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor t ...[more]