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Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

ABSTRACT: Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC₅₀ = 0.6 ± 0.1 µM, SI = 71.7).

SUBMITTER: Bourjot M

PROVIDER: S-EPMC6270878 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

Bourjot Mélanie M Leyssen Pieter P Neyts Johan J Dumontet Vincent V Litaudon Marc M

Molecules (Basel, Switzerland) 20140324 3

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. A ...[more]

PMID: 24662077

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