Ontology highlight
ABSTRACT:
SUBMITTER: Zhong M
PROVIDER: S-EPMC6271052 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhong Mei M Liu Yanjuan Y Liu Junxi J Di Duolong D Xu Mengrou M Yang Yaya Y Li Wenguang W Chen Yali Y Liu Jinxia J
Molecules (Basel, Switzerland) 20140812 8
In order to improve the anticancer activity of isocorydine (ICD), ten isocorydine derivatives were prepared through chemical structure modifications, and their in vitro and in vivo activities were experimentally investigated. 8-Amino-isocorydine (8) and 6a,7-dihydrogen-isocorydione (10) could inhibit the growth of human lung (A549), gastric (SGC7901) and liver (HepG2) cancer cell lines in vitro. Isocorydione (2) could inhibit the tumor growth of murine sarcoma S180-bearing mice, and 8-acetamino- ...[more]