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Diastereoselective three-component reactions of chiral nickel(II) glycinate for convenient synthesis of novel ?-amino-?-substituted-?,?-disubstituted butyric acids.


ABSTRACT: The convenient, high yielding and diastereoselective synthesis of ?-amino-?-substituted-?,?-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to ?-amino-?-substituted-?,?-disubstituted butyric acid derivatives.

SUBMITTER: Zhou R 

PROVIDER: S-EPMC6271210 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Diastereoselective three-component reactions of chiral nickel(II) glycinate for convenient synthesis of novel α-amino-β-substituted-γ,γ-disubstituted butyric acids.

Zhou Rui R   Guo Li L   Peng Cheng C   He Gu G   Ouyang Liang L   Huang Wei W  

Molecules (Basel, Switzerland) 20140110 1


The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives. ...[more]

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