Ontology highlight
ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC6271210 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20140110 1
The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives. ...[more]