Ontology highlight
ABSTRACT:
SUBMITTER: Ng CH
PROVIDER: S-EPMC6271415 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ng Chean Hui CH Rullah Kamal K Aluwi Mohd Fadhlizil Fasihi Mohd MF Abas Faridah F Lam Kok Wai KW Ismail Intan Safinar IS Narayanaswamy Radhakrishnan R Jamaludin Fadzureena F Shaari Khozirah K
Molecules (Basel, Switzerland) 20140805 8
The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides. The search for selective LOX inhibitors may provide new therapeutic approach for inflammatory diseases. Herein, we report the sy ...[more]