Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity.
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ABSTRACT:
SUBMITTER: Taha M
PROVIDER: S-EPMC6271482 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity.
Taha Muhammad M Naz Humera H Rasheed Saima S Ismail Nor Hadiani NH Rahman Aqilah Abd AA Yousuf Sammer S Choudhary Muhammad Iqbal MI
Molecules (Basel, Switzerland) 20140121 1
A series of 4-methoxybenzoylhydrazones 1-30 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC50 values ranging between 216.52 and 748.71 µM, when compared to a rutin standard (IC50=294.46±1.50 µM). Compounds 1 (IC50=216.52±4.2 µM), 3 (IC50=289.58±2.64 µM), 6 (IC50=227.75±0.53 µM), 7 (IC50=242.53±6.1) and 11 (IC50=287.79±1.59) all showed more activity that the standard, and ...[more]
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