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Facile synthesis of bis(indolyl)methanes catalyzed by ?-chymotrypsin.

ABSTRACT: A mild and efficient method catalyzed by ?-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little ?-chymotrypsin as catalyst.

SUBMITTER: Xie ZB

PROVIDER: S-EPMC6271608 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Facile synthesis of bis(indolyl)methanes catalyzed by α-chymotrypsin.

Xie Zong-Bo ZB Sun Da-Zhao DZ Jiang Guo-Fang GF Le Zhang-Gao ZG

Molecules (Basel, Switzerland) 20141127 12

A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst. ...[more]

PMID: 25438078

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