Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6271681 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Zhang Wei W Ai Jing J Shi Dakuo D Peng Xia X Ji Yinchun Y Liu Jian J Geng Meiyu M Li Yingxia Y
Molecules (Basel, Switzerland) 20140224 2
A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indicated that five compounds exhibited significant inhibitory effect on c-Met with IC50 values of 8.6-81 nM and four compounds showed potent inhibitory activity against MKN45 cell proliferation, with IC50s ranging from 0.57-16 μM. ...[more]