Unknown

Dataset Information

0

Discovery of novel c-Met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold.


ABSTRACT: A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indicated that five compounds exhibited significant inhibitory effect on c-Met with IC50 values of 8.6-81 nM and four compounds showed potent inhibitory activity against MKN45 cell proliferation, with IC50s ranging from 0.57-16 ?M.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6271681 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Discovery of novel c-Met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold.

Zhang Wei W   Ai Jing J   Shi Dakuo D   Peng Xia X   Ji Yinchun Y   Liu Jian J   Geng Meiyu M   Li Yingxia Y  

Molecules (Basel, Switzerland) 20140224 2


A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indicated that five compounds exhibited significant inhibitory effect on c-Met with IC50 values of 8.6-81 nM and four compounds showed potent inhibitory activity against MKN45 cell proliferation, with IC50s ranging from 0.57-16 μM. ...[more]

Similar Datasets

| S-EPMC5150693 | biostudies-literature
| S-EPMC10790229 | biostudies-literature
| S-EPMC4027597 | biostudies-literature
| S-EPMC6272887 | biostudies-literature
| S-EPMC7726787 | biostudies-literature
| S-EPMC7153915 | biostudies-literature
| S-EPMC7364574 | biostudies-literature
| S-EPMC6232652 | biostudies-literature
| S-EPMC5494638 | biostudies-literature
| S-EPMC6097228 | biostudies-literature