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A new prenylated indole diketopiperazine alkaloid from Eurotium cristatum.

ABSTRACT: A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey's method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.

SUBMITTER: Zou X

PROVIDER: S-EPMC6271712 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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A new prenylated indole diketopiperazine alkaloid from Eurotium cristatum.

Zou Xianwei X Li Ying Y Zhang Xiaona X Li Qian Q Liu Xuan X Huang Yun Y Tang Tao T Zheng Saijing S Wang Weimiao W Tang Jintian J

Molecules (Basel, Switzerland) 20141103 11

A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey's method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, a ...[more]

PMID: 25372398

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