Ontology highlight
ABSTRACT:
SUBMITTER: Alagia A
PROVIDER: S-EPMC6271724 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Alagia Adele A Terrazas Montserrat M Eritja Ramon R
Molecules (Basel, Switzerland) 20141104 11
The RNA interference pathway (RNAi) is a specific and powerful biological process, triggered by small non-coding RNA molecules and involved in gene expression regulation. In this work, we explored the possibility of increasing the biological stability of these RNA molecules by replacing their natural ribose ring with an acyclic L-threoninol backbone. In particular, this modification has been incorporated at certain positions of the oligonucleotide strands and its effects on the biological proper ...[more]