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Three new ring-A modified ursane triterpenes from Davidia involucrata.

ABSTRACT: Three new ursane triterpenes, 3?,19?-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19?,23-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19?,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with six known compounds. Their structures were elucidated by means of various spectroscopic analyses. The isolated triterpenes provide important evolutionary and chemotaxonomic knowledge about the monotypic genus Davidia. Five of the identified compounds showed moderate cytotoxicities against the cell proliferation of SGC-7901, MCF-7, and BEL-7404 with IC50 range from 7.26 to 47.41 ?M.

SUBMITTER: Tan QW

PROVIDER: S-EPMC6271727 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Three new ring-A modified ursane triterpenes from Davidia involucrata.

Tan Qing-Wei QW Ouyang Ming-An MA Gao Bo B

Molecules (Basel, Switzerland) 20140417 4

Three new ursane triterpenes, 3α,19α-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19α,23-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19α,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with six known compounds. Their structures were elucidated by means of various spectroscopic analyses. The isolated triterpenes provide important evolutionary and chemotaxonomic k ...[more]

PMID: 24747647

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