Ontology highlight
ABSTRACT:
SUBMITTER: Yuan JW
PROVIDER: S-EPMC6271756 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20140603 6
A series of caffeic acid amides D1-D17 bearing 2,3,4,5-tetrahydrobenzo-[b][1,4]dioxocine units has been synthesized and their biological activities evaluated for potential antiproliferative and EGFR inhibitory activity. Of all the compounds studied, compound D9 showed the most potent inhibitory activity (IC50=0.79 μM for HepG2 and IC50=0.36 μM for EGFR). The structures of compounds were confirmed by 1H-NMR, ESI-MS and elemental analysis. Among all, the structure of compound D9 ((E)-N-(4-ethoxyph ...[more]