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Two new acylated flavonol glycosides from the seeds of Lepidium sativum.

ABSTRACT: Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-?-D-galactopyranosyl-(1 ? 2)-?-D-glucopyranoside-7-O-?-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-?-D-glucopyranosyl-(1 ? 3)-?-D-galactopyranoside-7-O-?-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 25.36 and 25.08 µM, respectively.

SUBMITTER: Fan QL

PROVIDER: S-EPMC6271768 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Two new acylated flavonol glycosides from the seeds of Lepidium sativum.

Fan Qing-Lu QL Zhu Yin-Di YD Huang Wen-Hua WH Qi Yun Y Guo Bao-Lin BL

Molecules (Basel, Switzerland) 20140731 8

Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1 → 2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1 → 3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysacc ...[more]

PMID: 25090122

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