Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus.
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ABSTRACT:
SUBMITTER: Sparzak B
PROVIDER: S-EPMC6272180 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus.
Sparzak Barbara B Krauze-Baranowska Mirosława M Kawiak Anna A Sowiński Paweł P
Molecules (Basel, Switzerland) 20150430 5
A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an I ...[more]
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