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Synthesis of novel bis-1,5-disubstituted-1H-tetrazoles by an efficient catalyst-free Ugi-azide repetitive process.

ABSTRACT: A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%-95%) or using mild MW-heating conditions (80%-91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds.

SUBMITTER: Cardenas-Galindo LE

PROVIDER: S-EPMC6272218 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Synthesis of novel bis-1,5-disubstituted-1H-tetrazoles by an efficient catalyst-free Ugi-azide repetitive process.

Cárdenas-Galindo Luís E LE Islas-Jácome Alejandro A Colmenero-Martínez Karla M KM Martínez-Richa Antonio A Gámez-Montaño Rocío R

Molecules (Basel, Switzerland) 20150116 1

A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%-95%) or using mild MW-heating conditions (80%-91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds. ...[more]

PMID: 25608852

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