Ontology highlight
ABSTRACT:
SUBMITTER: Zhong D
PROVIDER: S-EPMC6272327 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhong Dongwei D Liu Mingming M Cao Yang Y Zhu Yelin Y Bian Shihui S Zhou Jiayi J Wu Fengjie F Ryu Kum-Chol KC Zhou Lu L Ye Deyong D
Molecules (Basel, Switzerland) 20150416 4
Analogues or isosteres of α,γ-diketoacid (DKA) 1a show potent inhibition of hepatitis C virus (HCV) NS5B polymerase through chelation of the two magnesium ions at the active site. The anti-HCV activity of the flavonoid quercetin (2) could partly be attributed to it being a structural mimic of DKAs. In order to delineate the structural features required for the inhibitory effect and improve the anti-HCV potency, two novel types of quercetin analogues, 7-O-arylmethylquercetins and quercetin-3-O-be ...[more]