Ontology highlight
ABSTRACT:
SUBMITTER: Wong VK
PROVIDER: S-EPMC6272412 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Wong Vincent Kam Wai VK Wu An Guo AG Wang Jing Rong JR Liu Liang L Law Betty Yuen-Kwan BY
Molecules (Basel, Switzerland) 20150218 3
Mutant huntingtin aggregation is highly associated with the pathogenesis of Huntington's disease, an adult-onset autosomal dominant disorder, which leads to a loss of motor control and decline in cognitive function. Recent literature has revealed the protective role of autophagy in neurodegenerative diseases through degradation of mutant toxic proteins, including huntingtin or a-synuclein. Through the GFP-LC3 autophagy detection platform, we have identified neferine, isolated from the lotu ...[more]