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New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens.

ABSTRACT: Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 ?M.

SUBMITTER: Wu Q

PROVIDER: S-EPMC6272480 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens.

Wu Qian Q Li Hua H Lee So Yoon SY Lee Hwa Jin HJ Ryu Jae-Ha JH

Molecules (Basel, Switzerland) 20150210 2

Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 μM. ...[more]

PMID: 25690283

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