Dataset Information

Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla.

ABSTRACT: One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of Liriope platyphylla aerial parts, along with seventeen known compounds. The structures of the isolates were established by spectroscopic analysis and comparison with the literature data. The results indicated that structures 1-3 are uncommon in Nature. Benzofuroisocoumarin 4, flavonoids 9, 10, and 13-15, and homoisoflavonoids 19 and 20 exhibited significant binding activity to estrogen-receptor ? and/or ? as demonstrated by the SEAP reporter assay system in an MCF-7 cell-line.

SUBMITTER: Tsai YC

PROVIDER: S-EPMC6272546 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla.

Tsai Yu-Chi YC Hsu Chia-Chun CC El-Shazly Mohamed M Chiang Shang-Yu SY Wu Chau-Chung CC Wu Chin-Chung CC Lai Wan-Chun WC Yen Ming-Hong MH Wu Yang-Chang YC Chang Fang-Rong FR

Molecules (Basel, Switzerland) 20150416 4

One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of Liriope platyphylla aerial parts, along with seventeen known compounds. The structures of the isolates were established by spectroscopic analysis and comparison with the literature data. The results indicated that st ...[more]

PMID: 25913925

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Dataset Information

Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla.

Publications

Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla.

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