(-)-Tarchonanthuslactone exerts a blood glucose-increasing effect in experimental type 2 diabetes mellitus.
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ABSTRACT:
SUBMITTER: de Souza GF
PROVIDER: S-EPMC6272554 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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(-)-Tarchonanthuslactone exerts a blood glucose-increasing effect in experimental type 2 diabetes mellitus.
de Souza Gabriela F P GF Novaes Luiz F T LF Avila Carolina M CM Nascimento Lucas F R LF Velloso Licio A LA Pilli Ronaldo A RA
Molecules (Basel, Switzerland) 20150319 3
A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative ...[more]
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