Ontology highlight
ABSTRACT:
SUBMITTER: Lange L
PROVIDER: S-EPMC6273375 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Lange Linda L Heisel Stefan S Sadowski Gabriele G
Molecules (Basel, Switzerland) 20160507 5
In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acetate at 298.15 K and in the ethanol/ethyl acetate mixture also at 310.15 K. The solubility of the invest ...[more]