Unknown

Dataset Information

0

Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures.


ABSTRACT: In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acetate at 298.15 K and in the ethanol/ethyl acetate mixture also at 310.15 K. The solubility of the investigated cocrystal slightly increased when adding small amounts of anti-solvent to the solvent, but drastically decreased for high anti-solvent amounts. Furthermore, the solubilities of nicotinamide, succinic acid and the cocrystal in the considered solvent/anti-solvent mixtures showed strong deviations from ideal-solution behavior. However, by accounting for the thermodynamic non-ideality of the components, PC-SAFT is able to predict the solubilities in all above-mentioned solvent/anti-solvent systems in good agreement with the experimental data.

SUBMITTER: Lange L 

PROVIDER: S-EPMC6273375 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures.

Lange Linda L   Heisel Stefan S   Sadowski Gabriele G  

Molecules (Basel, Switzerland) 20160507 5


In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acetate at 298.15 K and in the ethanol/ethyl acetate mixture also at 310.15 K. The solubility of the invest  ...[more]

Similar Datasets

| S-EPMC2690398 | biostudies-other
| S-EPMC7828412 | biostudies-literature
| S-EPMC7291792 | biostudies-literature
| S-EPMC8706418 | biostudies-literature
| S-EPMC8424375 | biostudies-literature
| S-EPMC8057229 | biostudies-literature
| S-EPMC2532981 | biostudies-literature
| S-EPMC5897543 | biostudies-literature
| S-EPMC6964257 | biostudies-literature
| S-EPMC7097992 | biostudies-literature