Ontology highlight
ABSTRACT:
SUBMITTER: Ordonez M
PROVIDER: S-EPMC6273407 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Ordóñez Mario M Arizpe Alicia A Sayago Fracisco J FJ Jiménez Ana I AI Cativiela Carlos C
Molecules (Basel, Switzerland) 20160831 9
We report here a practical and efficient synthesis of α-aminophosphonic acid incorporated into 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroisoquinoline heterocycles, which could be considered to be conformationally constrained analogues of pipecolic acid. The principal contribution of this synthesis is the introduction of the phosphonate group in the N-acyliminium ion intermediates, obtained from activation of the quinoline and isoquinoline heterocycles or from the appropriate δ-lactam wit ...[more]