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Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii.

ABSTRACT: Chemical investigation of the 90% acetone extract of the branches and leaves of Sabina gaussenii led to the isolation of two new cinnamyl isovalerate derivatives (1-2) and eighteen known compounds (3-20). Their structures were determined mainly by means of MS, 1D- and 2D-NMR data, and this is the first time these compounds have been reported from this plant. The biological activity test results indicated that the 90% acetone extract showed cytotoxicity against the human lung adenocarcinoma (A549) cell line (IC50 = 0.98 ± 0.1 ?g/mL), compound 6 showed cytotoxicities against human cervical carcinoma (HeLa) (IC50 = 0.4 ± 0.1 ?M ) and human gastric carcinoma (BGC-823) (IC50 = 0.9 ± 0.2 ?M) cancer cell lines, and compound 19 showed cytotoxicities against HeLa (IC50 = 1.5 ± 0.4 ?M), BGC-823 (IC50 = 7.0 ± 0.8 ?M ), and A549 (IC50 = 10.6 ± 1.5 ?M ) cancer cell lines.

SUBMITTER: Sun ZH

PROVIDER: S-EPMC6273497 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii.

Sun Zhang-Hua ZH Tan Ning-Hua NH Zeng Guang-Zhi GZ Zhang Yu-Mei YM

Molecules (Basel, Switzerland) 20160429 5

Chemical investigation of the 90% acetone extract of the branches and leaves of Sabina gaussenii led to the isolation of two new cinnamyl isovalerate derivatives (1-2) and eighteen known compounds (3-20). Their structures were determined mainly by means of MS, 1D- and 2D-NMR data, and this is the first time these compounds have been reported from this plant. The biological activity test results indicated that the 90% acetone extract showed cytotoxicity against the human lung adenocarcinoma (A549 ...[more]

PMID: 27136522

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