Unknown

Dataset Information

0

Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity.


ABSTRACT: Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriarianepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds 1-3 and five semisynthetic congeners (1a-e) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative 1c and nepalarin (3) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.

SUBMITTER: Wang YY 

PROVIDER: S-EPMC6273530 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity.

Wang Yuan-Yuan YY   Tian Jun-Mian JM   Zhang Cheng-Chen CC   Luo Bo B   Gao Jin-Ming JM  

Molecules (Basel, Switzerland) 20161012 10


Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (<b>1</b>) and B (<b>2</b>), and one new coumarin, nepalarin (<b>3</b>), were isolated from the root barks of the poisonous plant <i>Coriaria</i><i>nepalensis</i>. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds <b>1</b>-<b>3</b> and five semisynthetic congeners (<b>1a</b>-<b>e</b>) were assayed for the activity to induce  ...[more]

Similar Datasets

| S-EPMC4724660 | biostudies-literature
| S-EPMC6017781 | biostudies-literature
| S-EPMC6152036 | biostudies-literature
| S-EPMC7766762 | biostudies-literature
| S-EPMC6514664 | biostudies-literature
| S-EPMC7277383 | biostudies-literature
| S-EPMC6155810 | biostudies-literature
| S-EPMC5581169 | biostudies-literature
| S-EPMC8685952 | biostudies-literature
| S-EPMC6471333 | biostudies-literature