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2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia.

ABSTRACT: Three new2-(2-phenylethyl)chromone derivatives (1-3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5-6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1-4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 5.76 to 20.1 µM.

SUBMITTER: Shao H

PROVIDER: S-EPMC6273548 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia.

Shao Hang H Mei Wen-Li WL Dong Wen-Hua WH Gai Cui-Juan CJ Li Wei W Zhu Guo-Peng GP Dai Hao-Fu HF

Molecules (Basel, Switzerland) 20161003 10

Three new2-(2-phenylethyl)chromone derivatives (1-3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5-6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1-4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, ...[more]

PMID: 27706109

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Three New 2-(2-Phenylethyl)chromone Derivatives of Agarwood Originated from Gyrinops salicifolia.

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