DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization.
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ABSTRACT:
SUBMITTER: Addamiano C
PROVIDER: S-EPMC6274049 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization.
Addamiano Claudia C Gerland Béatrice B Payrastre Corinne C Escudier Jean-Marc JM
Molecules (Basel, Switzerland) 20160823 9
Construction and physico-chemical behavior of DNA three way junction (3WJ) functionalized by protein-like residues (imidazole, alcohol and carboxylic acid) at unpaired positions at the core is described. One 5'-C(S)-propargyl-thymidine nucleotide was specifically incorporated on each strand to react through a post synthetic CuACC reaction with either protected imidazolyl-, hydroxyl- or carboxyl-azide. Structural impacts of 5'-C(S)-functionalization were investigated to evaluate how 3WJ flexibili ...[more]
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