Ontology highlight
ABSTRACT:
SUBMITTER: Fernandes SD
PROVIDER: S-EPMC6274114 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Fernandes Sílvia D SD Porta Riccardo R Barrulas Pedro C PC Puglisi Alessandra A Burke Anthony J AJ Benaglia Maurizio M
Molecules (Basel, Switzerland) 20160906 9
The stereoselective reduction of imines with trichlorosilane catalyzed by chiral Lewis bases is a well-established procedure for the synthesis of enantio-enriched amines. Five supported cinchona-based picolinamides have been prepared and their activity tested in a model reaction. The comparison of different supporting materials revealed that polystyrene gave better results than silica in terms of stereoselectivity. The applicability of the solid-supported catalyst of choice to the reduction of d ...[more]