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Taxanes in the Treatment of Advanced Gastric Cancer.

ABSTRACT: Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of taxanes in the first- or second-line chemotherapy setting for AGC.

SUBMITTER: Kang BW 

PROVIDER: S-EPMC6274234 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Taxanes in the Treatment of Advanced Gastric Cancer.

Kang Byung Woog BW   Kwon Oh-Kyoung OK   Chung Ho Young HY   Yu Wansik W   Kim Jong Gwang JG  

Molecules (Basel, Switzerland) 20160517 5

Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of tax  ...[more]

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