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New 30-Noroleanane Triterpenoid Saponins from Holboellia coriacea Diels.

ABSTRACT: Three new 30-noroleanane triterpenoid saponins, akebonoic acid 28-O-?-d-glucopyranosyl-(1''?6')-?-d-glucopyranosyl ester (1), akebonoic acid 28-O-(6''-O-caffeoyl)-?-d-glucopyranosyl-(1''?6')-?-d-glucopyranosyl ester (Holboelliside A, 2) and 3?,20?,24-trihydroxy-29-norolean-12-en-28-oic acid 3-O-(6'-O-caffeoyl)-?-d-glucopyranoside (Holboelliside B, 3) were isolated from the stems of Holboellia coriacea Diels, together with five known compounds, eupteleasaponin VIII (4), 3?-akebonoic acid (5), quinatic acid (6), 3?-hydroxy-30-norhederagenin (7) and quinatoside A (8). The structures of these compounds were determined on the basis of spectral and chemical evidence. Compounds 1-5 were evaluated for their inhibitory activity against three human tumors HepG2, HCT116 and SGC-7901 cell lines in vitro.

SUBMITTER: Ding W

PROVIDER: S-EPMC6274467 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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New 30-Noroleanane Triterpenoid Saponins from Holboellia coriacea Diels.

Ding Wenbing W Li Ye Y Li Guanhua G He Hualiang H Li Zhiwen Z Li Youzhi Y

Molecules (Basel, Switzerland) 20160604 6

Three new 30-noroleanane triterpenoid saponins, akebonoic acid 28-O-β-d-glucopyranosyl-(1''→6')-β-d-glucopyranosyl ester (1), akebonoic acid 28-O-(6''-O-caffeoyl)-β-d-glucopyranosyl-(1''→6')-β-d-glucopyranosyl ester (Holboelliside A, 2) and 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 3-O-(6'-O-caffeoyl)-β-d-glucopyranoside (Holboelliside B, 3) were isolated from the stems of Holboellia coriacea Diels, together with five known compounds, eupteleasaponin VIII (4), 3α-akebonoic acid (5), qui ...[more]

PMID: 27271590

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