Ontology highlight
ABSTRACT:
SUBMITTER: Pedro L
PROVIDER: S-EPMC6274484 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20160728 8
The advent of native mass spectrometry (MS) in 1990 led to the development of new mass spectrometry instrumentation and methodologies for the analysis of noncovalent protein-ligand complexes. Native MS has matured to become a fast, simple, highly sensitive and automatable technique with well-established utility for fragment-based drug discovery (FBDD). Native MS has the capability to directly detect weak ligand binding to proteins, to determine stoichiometry, relative or absolute binding affinit ...[more]