Ontology highlight
ABSTRACT:
SUBMITTER: Liang Y
PROVIDER: S-EPMC6274620 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Liang Yang Y Tebaldi Toma T Rejeski Kai K Joshi Poorval P Stefani Giovanni G Taylor Ashley A Song Yuanbin Y Vasic Radovan R Maziarz Jamie J Balasubramanian Kunthavai K Ardasheva Anastasia A Ding Alicia A Quattrone Alessandro A Halene Stephanie S
Leukemia 20180601 12
Recurrent mutations in the splicing factor SRSF2 are associated with poor clinical outcomes in myelodysplastic syndromes (MDS). Their high frequency suggests these mutations drive oncogenesis, yet the molecular explanation for this process is unclear. SRSF2 mutations could directly affect pre-mRNA splicing of a vital gene product; alternatively, a whole network of gene products could be affected. Here we determine how SRSF2 mutations globally affect RNA binding and splicing in vivo using HITS-CL ...[more]