Ontology highlight
ABSTRACT:
SUBMITTER: Fan G
PROVIDER: S-EPMC6274648 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Fan Guizhen G Baker Mariah R MR Wang Zhao Z Seryshev Alexander B AB Ludtke Steven J SJ Baker Matthew L ML Serysheva Irina I II
Cell research 20181123 12
Inositol-1,4,5-trisphosphate receptors (InsP<sub>3</sub>Rs) are cation channels that mobilize Ca<sup>2+</sup> from intracellular stores in response to a wide range of cellular stimuli. The paradigm of InsP<sub>3</sub>R activation is the coupled interplay between binding of InsP<sub>3</sub> and Ca<sup>2+</sup> that switches the ion conduction pathway between closed and open states to enable the passage of Ca<sup>2+</sup> through the channel. However, the molecular mechanism of how the receptor se ...[more]