Ontology highlight
ABSTRACT:
SUBMITTER: Eckstein M
PROVIDER: S-EPMC6274690 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Eckstein Markus M Wirtz Ralph Markus RM Gross-Weege Matthias M Breyer Johannes J Otto Wolfgang W Stoehr Robert R Sikic Danijel D Keck Bastian B Eidt Sebastian S Burger Maximilian M Bolenz Christian C Nitschke Katja K Porubsky Stefan S Hartmann Arndt A Erben Philipp P
International journal of molecular sciences 20181030 11
Recently, muscle-invasive bladder cancer (MIBC) has been subclassified by gene expression profiling, with a substantial impact on therapy response and patient outcome. We tested whether these complex molecular subtypes of MIBC can be determined by mRNA detection of keratin 5 (<i>KRT5</i>) and keratin 20 (<i>KRT20</i>). Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) was applied to quantify gene expression of <i>KRT5</i> and <i>KRT20</i> using TaqMan<sup>®</sup>-based assay ...[more]