Dynamic Collision Behavior Between Osteoblasts and Tumor Cells Regulates the Disordered Arrangement of Collagen Fiber/Apatite Crystals in Metastasized Bone.
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ABSTRACT:
SUBMITTER: Matsugaki A
PROVIDER: S-EPMC6274720 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Dynamic Collision Behavior Between Osteoblasts and Tumor Cells Regulates the Disordered Arrangement of Collagen Fiber/Apatite Crystals in Metastasized Bone.
Matsugaki Aira A Harada Tatsuki T Kimura Yumi Y Sekita Aiko A Nakano Takayoshi T
International journal of molecular sciences 20181105 11
Bone metastasis is one of the most intractable bone diseases; it is accompanied with a severe mechanical dysfunction of bone tissue. We recently discovered that the disorganized collagen/apatite microstructure in cancer-bearing bone is a dominant determinant of the disruption of bone mechanical function; disordered osteoblast arrangement was found to be one of the principal determinants of the deteriorated collagen/apatite microstructure. However, the precise molecular mechanisms regulating the ...[more]
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