Physical activity and epigenetic biomarkers in maternal blood during pregnancy.
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ABSTRACT: Aim
Investigate associations of leisure time physical activity (LTPA) with DNA methylation and miRNAs during pregnancy. Patients & methods: LTPA, candidate DNA methylation and circulating miRNAs were measured (average 15 weeks gestation) in pregnant women (n = 92).Results
Each additional hour of prepregnancy LTPA duration was associated with hypermethylation in C1orf212 (? = 0.137, 95% CI: 0.004-0.270) and higher circulating miR-146b-5p (? = 0.084, 95% CI: 0.017-0.151). Each additional metabolic equivalent hour of early-pregnancy LTPA energy expenditure was associated with higher circulating miR-21-3p (? = 0.431, 95% CI: 0.089-0.772) in women carrying female offspring, and lower circulating miR-146b-5p (? = -0.285, 95% CI: -0.528 to -0.043) and miR-517-5p (? = -0.406, 95% CI: -0.736 to -0.076) in women carrying male offspring.Conclusion
Our findings suggest that LTPA may influence maternal epigenetic biomarkers, possibly in an offspring sex-specific manner.
SUBMITTER: Badon SE
PROVIDER: S-EPMC6275564 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Physical activity and epigenetic biomarkers in maternal blood during pregnancy.
Badon Sylvia E SE Littman Alyson J AJ Chan Kwun Chuen Gary KCG Tadesse Mahlet G MG Stapleton Patricia L PL Bammler Theo K TK Sorensen Tanya K TK Williams Michelle A MA Enquobahrie Daniel A DA
Epigenomics 20181016 11
<h4>Aim</h4>Investigate associations of leisure time physical activity (LTPA) with DNA methylation and miRNAs during pregnancy. Patients & methods: LTPA, candidate DNA methylation and circulating miRNAs were measured (average 15 weeks gestation) in pregnant women (n = 92).<h4>Results</h4>Each additional hour of prepregnancy LTPA duration was associated with hypermethylation in C1orf212 (β = 0.137, 95% CI: 0.004-0.270) and higher circulating miR-146b-5p (β = 0.084, 95% CI: 0.017-0.151). Each addi ...[more]
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