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Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects.

ABSTRACT: BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.

SUBMITTER: Lima LRP

PROVIDER: S-EPMC6276022 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects.

Lima Lyana Rodrigues Pinto LRP Araújo Nathália Alves de NA Guterres Alexandro A Pilotto José Henrique JH Niel Christian C Paula Vanessa Salete de VS

Memorias do Instituto Oswaldo Cruz 20181203 12

BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable g ...[more]

PMID: 30517210

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