Ontology highlight
ABSTRACT:
SUBMITTER: Rawle RJ
PROVIDER: S-EPMC6276045 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Rawle Robert J RJ Webster Elizabeth R ER Jelen Marta M Kasson Peter M PM Boxer Steven G SG
ACS central science 20181012 11
The recent spread of Zika virus stimulated extensive research on its structure, pathogenesis, and immunology, but mechanistic study of entry has lagged behind, in part due to the lack of a defined reconstituted system. Here, we report Zika membrane fusion measured using a platform that bypasses these barriers, enabling observation of single-virus fusion kinetics without receptor reconstitution. Surprisingly, target membrane binding and low pH are sufficient to trigger viral hemifusion to liposom ...[more]