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Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?

ABSTRACT: The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colorectal cancer (CRC) is among the most common malignancies and causes millions of deaths worldwide every year. In this review, we discuss the status and perspective of the ACT in the treatment of CRC.

SUBMITTER: Fan J

PROVIDER: S-EPMC6276301 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?

Fan Jiaqiao J Shang Dong D Han Bing B Song Jianxun J Chen Hailong H Yang Jin-Ming JM

Theranostics 20181110 20

The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer. Utilization of ACT can enhance the function of the immune system or improve the specificity and persistence of transferred cells. Various immune cells including T lymphocytes, natural killer cells, dendritic cells, and even stem cells can be used in the ACT despite their different functional mechanisms. Colo ...[more]

PMID: 30555581

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