Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6276310 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wang Shiyu S Allen Nickolas N Liang Xue-Hai XH Crooke Stanley T ST
Molecular therapy. Nucleic acids 20181024
Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools. PS-ASOs can enter cells via endocytic pathways and escape from membrane-enclosed endocytic organelles to reach target RNAs. We recently found that lysobisphosphatidic acid is required for release of PS-ASOs from late endosomes. Here, we evaluated the effects of other lipids on PS-ASO intracellular traffic ...[more]