Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez P
PROVIDER: S-EPMC6277155 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Vázquez Patricia P Hernández-Sánchez Catalina C Escalona-Garrido Carmen C Pereira Laura L Contreras Cristina C López Miguel M Balsinde Jesús J de Pablo Flora F Valverde Ángela M ÁM
Journal of lipid research 20181023 12
Tyrosine hydroxylase (TH) catalyzes the first step in catecholamines synthesis. We studied the impact of reduced TH in brown adipose tissue (BAT) activation. In adult heterozygous (<i>Th<sup>+/-</sup></i> ) mice, dopamine and noradrenaline (NA) content in BAT decreased after cold exposure. This reduced catecholaminergic response did not impair cold adaptation, because these mice induced uncoupling protein 1 (UCP-1) and maintained BAT temperature to a similar extent than controls (<i>Th<sup>+/+</ ...[more]