Ontology highlight
ABSTRACT:
SUBMITTER: Beddoes CM
PROVIDER: S-EPMC6277170 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Beddoes Charlotte M CM Gooris Gert S GS Bouwstra Joke A JA
Journal of lipid research 20181017 12
The lipid matrix of the stratum corneum, the outermost skin layer, consists primarily of ceramides, cholesterol, and FFAs. These lipids form a trilayer long-periodicity phase (LPP) that is unique to this barrier. Knowledge about the LPP is essential in understanding the barrier function. Previous studies of LPP lipid models have identified the position of the major lipid classes and suggested that a large fraction of FFAs and the ceramide acyl chain are present in the central region. However, th ...[more]