Bidirectional Role of ?2-Adrenergic Receptor in Autoimmune Diseases.

ABSTRACT: Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (?2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of ?2-AR, as well as different subtypes of G? binding to ?2-AR. In this review, we summarize the actions of ?2-AR signaling in regulating the functions of immunocytes and in the pathogenesis of ADs, and the application of ?2-AR agonists or antagonists in treating major types of ADs is also discussed. We suggest that restoring the immune balance via a soft regulation of the expression or activation of ?2-AR is one of the promising therapeutic strategies for systematic ADs.

SUBMITTER: Wu L 

PROVIDER: S-EPMC6277539 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature