Ontology highlight
ABSTRACT:
SUBMITTER: Bonnefoy F
PROVIDER: S-EPMC6277856 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bonnefoy Francis F Gauthier Thierry T Vallion Romain R Martin-Rodriguez Omayra O Missey Anais A Daoui Anna A Valmary-Degano Séverine S Saas Philippe P Couturier Mélanie M Perruche Sylvain S
Frontiers in immunology 20181113
Unresolved inflammation is a common feature in the pathogenesis of chronic inflammatory/autoimmune diseases. The factors produced by macrophages eliminating apoptotic cells during resolution are crucial to terminate inflammation, and for subsequent tissue healing. We demonstrated here that the factors produced by macrophages eliminating apoptotic cells were sufficient to reboot the resolution of inflammation <i>in vivo</i>, and thus definitively terminated ongoing chronic inflammation. These fac ...[more]