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ABSTRACT:
SUBMITTER: Edrees MM
PROVIDER: S-EPMC6278264 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Edrees Mastoura M MM Melha Sraa Abu- SA Saad Amirah M AM Kheder Nabila A NA Gomha Sobhi M SM Muhammad Zeinab A ZA
Molecules (Basel, Switzerland) 20181114 11
The one-pot synthesis of a series of pyrazoline derivatives containing the bioactive thiazole ring has been performed through a 1,3-dipolar cycloaddition reaction of <i>N</i>-thiocarbamoylpyrazoline and different hydrazonoyl halides or α-haloketones in the presence of DABCO (1,4-diazabicyclo[2.2.2] octane) as an eco-friendly catalyst using the solvent-drop grinding method. The structure of the synthesized compounds was elucidated using elemental and spectroscopic analyses (IR, NMR, and Mass). Th ...[more]